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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NAE1 All Species: 24.24
Human Site: S415 Identified Species: 41.03
UniProt: Q13564 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13564 NP_001018169.1 534 60246 S415 N K D E I I S S M D N P D N E
Chimpanzee Pan troglodytes XP_001159531 534 60179 S415 N K D E I I S S M D N P D N E
Rhesus Macaque Macaca mulatta XP_001085059 534 60247 S415 N K D E I I S S M D N P D N E
Dog Lupus familis XP_852003 534 60357 S415 N K D E I I S S M D N P D N E
Cat Felis silvestris
Mouse Mus musculus Q8VBW6 534 60255 S415 N K D E I I S S M D N P D N E
Rat Rattus norvegicus Q9Z1A5 534 60364 S415 N K D E I I S S M D N P D N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505632 525 59197 N406 N K D E I I S N M D N P D S E
Chicken Gallus gallus Q5ZIE6 535 60465 N416 N K D E I I S N M D N P D S E
Frog Xenopus laevis Q6NTW6 533 60607 L414 K K D D I V S L M E N P D N E
Zebra Danio Brachydanio rerio Q7SXP2 533 60386 C414 N K D E I T S C M D S P D S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VTE9 524 58698 L404 K S S R L L P L V E D N E L Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18217 541 60764 N409 V E K I R E S N I D E E T R N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42744 540 60016 A420 T E I Q K Y L A D E D Y S G A
Baker's Yeast Sacchar. cerevisiae Q12059 462 52834 S348 V E E S L A R S K K I V S Q D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.4 97.7 N.A. 97 96.8 N.A. 82.7 83.9 78.8 73 N.A. 45.1 N.A. 37.7 N.A.
Protein Similarity: 100 99.6 99.4 98.8 N.A. 98.6 98.3 N.A. 91.1 93 89.6 85.9 N.A. 64.2 N.A. 55.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 86.6 86.6 66.6 73.3 N.A. 0 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 86.6 86.6 N.A. 46.6 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 38.8 25.8 N.A.
Protein Similarity: N.A. N.A. N.A. 62.7 46.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 72 8 0 0 0 0 8 72 15 0 72 0 8 % D
% Glu: 0 22 8 65 0 8 0 0 0 22 8 8 8 0 72 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 72 58 0 0 8 0 8 0 0 0 0 % I
% Lys: 15 72 8 0 8 0 0 0 8 8 0 0 0 0 0 % K
% Leu: 0 0 0 0 15 8 8 15 0 0 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 72 0 0 0 0 0 0 % M
% Asn: 65 0 0 0 0 0 0 22 0 0 65 8 0 50 8 % N
% Pro: 0 0 0 0 0 0 8 0 0 0 0 72 0 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 8 % Q
% Arg: 0 0 0 8 8 0 8 0 0 0 0 0 0 8 0 % R
% Ser: 0 8 8 8 0 0 79 50 0 0 8 0 15 22 0 % S
% Thr: 8 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % T
% Val: 15 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _